Hcg To Raise Testosterone Levels

Hcg To Raise Testosterone Levels

BJU International

Andrology

Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study

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Corresponding Author

  • drmhabos@hotmail.com
  • orcid.org/0000-0002-4867-6646

Urology and Andrology Department, Elaj Medical Centres, Jeddah, Saudi Arabia

Correspondence: Dr Mohamad Habous, Consultant Urologist, Elaj Medical Group, 3047 Sari Street, Al-Faislia District, 21391 Jeddah, Saudi Arabia.

e-mail: drmhabos@hotmail.com

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Simone Giona , Alaa Tealab , Mohammed Aziz ,

Urology Department, Menoufia University, Shibin Al Kawm, Egypt

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Ben Williamson ,

University Hospitals Birmingham, Birmingham, UK

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Mohammed Nassar ,

Urology and Andrology Department, Elaj Medical Centres, Jeddah, Saudi Arabia

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Zeyad Abdelrahman ,

Urology and Andrology Department, Elaj Medical Centres, Jeddah, Saudi Arabia

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Abdallah Remeah ,

Urology and Andrology Department, Elaj Medical Centres, Jeddah, Saudi Arabia

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Mohamed Abdelkader ,

Urology and Andrology Department, Elaj Medical Centres, Jeddah, Saudi Arabia

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Saleh Binsaleh ,

Division of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia

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Gordon Muir ,

First published: 17 May 2018

Citations: 9

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Abstract

Objectives

To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies.

Patients and Methods

A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n = 95); 5000 IU hCG injections twice weekly (n = 94); or a combination of both therapies (CC + hCG; n = 94). All participants had complete medical history and had undergone thorough physical examination, including body mass index (BMI) assessment. Laboratory tests included serum total testosterone and glycated haemoglobin (HbA1c) measurements. Quantitative Androgen Deficiency in the Aging Male (qADAM) questionnaire scores were also recorded. Morning samples of total serum testosterone levels were assessed at three time points: baseline, 1 and 3 months.

Results

Testosterone levels increased at 1 and 3 months in all three groups. The mean baseline testosterone level was 2.31 ± 0.66 nmol/L, BMI was 30.8 ± 6.2 kg/m2, and qADAM score was 20.5 ± 3.8. Testosterone levels increased in all groups at all time points, with a final mean value of 5.17 ± 1.77 nmol/L (223% increase) with no statistically significant difference among the groups. qADAM scores had increased in all groups at 1 month (CC group: 6.36; hCG group: 5.08; CC + hCG group: 7.26) and at 3 months (CC group: 12.73; hCG group: 11.82; CC + hCG group: 15.13) with a significant difference in intergroup analysis for the CC + hCG group compared with the other two groups (P < 0.01).

Conclusions

All three treatments were equally effective in restoring testosterone levels. Single-agent CC is simple, cheap and may be used as treatment for hypogonadism when maintenance of fertility is desired. This approach seems to be as effective as either hCG alone or a combination of hCG and CC.

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Hcg To Raise Testosterone Levels

Source: https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.14401

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